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- Recombinant Human Sonic Hedgehog/Shh (C24II),BR
Recombinant Human Sonic Hedgehog/Shh (C24II),BR
Recombinant Human Sonic Hedgehog/Shh (C24II)
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产品属性 Product Attributes
基本信息
别名: Sonic Hedgehog Protein;SHH;HHG-1;SHH规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状): Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
产品信息
背景说明: Sonic Hedgehog Homolog (SHH) belongs to a three-protein family called Hedgehog.The other two family members are Indian Hedgehog (IHH) and Desert Hedgehog (DHH).Hedgehog proteins are key signaling molecules in embryonic development.SHH is expressed in various embryonic tissues and plays critical roles in regulating the patterning of many systems,such as limbs and brain.SHH also plays an important role in adult,including the division of adult stem cells and the development of certain cancers and other diseases.Human SHH is expressed as a 45kDa precursor,and undergoes a series of processing during secretion.After the removal of the signal peptide,a protease within the C-terminal domain catalyzes the cleavage of SHH into a 20 kDa N-terminal signaling domain (SHH-N) and a 25 kDa C-terminal domain (SHH-C).SHH-N has the “all signaling” capability.SHH-N binds to the 12 pass transmembrane protein Patched (Ptc) on cell surface,which releases the repression of the activity of Smoothened (Smo),a G-protein coupled receptor,by Ptc.来源: E.coli
其它标识
溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.
产品介绍 Product Introduction
暂无数据注意事项 Considerations
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。2.为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响,相关处理只限于产品本身,不涉及其他赔偿。