Recombinant Mouse Legumain/Asparaginyl Endopeptidase/AEP,BR

产品属性 Product Attributes

基本信息

别名： Legumain;Lgmn;Asparaginyl endopeptidase;Protease cysteine 1;Prsc1
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Supplied as a 0.2 μm filtered solution of 20mM Tris,150mM NaCl,20% Glycerol,pH8.0.Note:The enzyme achieves its activity under acidic pH.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

产品信息

背景说明： Mouse Legumain，also known as LGMN，is a cysteine protease belonging to peptidase family C13 and is expressed in kidney and placenta abundantly.LGMN has a strict specificity for hydrolysis of asparaginyl bonds.It can also cleave aspartyl bonds slowly，especially under acidic conditions.The mammalian legumain is involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.It plays a role in the regulation of cell proliferation via its role in EGFR degradation.Legumain deficiency causes the accumulation of pro-Cathepsins B，H and L，another group of lysosomal cysteine proteases.Overexpression of Legumain in tumors is significant for invasion/metastasis.Mammalian legumain is inhibited by iodoacetamide and maleimides.Legumain activation appears to be autocatalytic and can be triggered by acidic pH.
来源： Human Cells

其它标识

内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。