Recombinant Human Neprilysin/CD10,BR

产品属性 Product Attributes

基本信息

别名： Neprilysin;Atriopeptidase;Common acute lymphocytic leukemia antigen;CALLA;Enkephalinase;Neutral endopeptidase 24.11;NEP;Neutral endopeptidase;Skin fibroblast elastase;SFE;CD10;MME;EPN
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Supplied as a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

产品信息

背景说明： Neprilysin/CD10(NEP) is a zinc metallopeptidase expressed at the cell surface of a variety of cells.The functions is both as an endopeptidase with a thermolysin-like specificity and as a dipeptidyl-carboxypeptidase.NEP has been shown to be involved in the degradation of enkephalins in the mammalian brain and the inactivation of circulating atrial natriuretic peptide.NEP has also been identified as the common acute lymphocytic leukemia antigen (CALLA)，and is expressed on the surface of lymphocytes in some disease states.These and other observations have resulted in considerable interest in NEP as a target for analgesics and antihypertensive drugs.NEP is also a major degrading enzyme of amyloid β peptide (Aβ) in the brain，indicating that down-regulation of NEP activity，which could be caused by aging，can contribute to the development of Alzheimer’s disease by promoting Aβ accumulation.
来源： Human Cells

其它标识

内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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注意事项 Considerations

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