Recombinant Human Lysine--tRNA ligase/KARS,BR

产品属性 Product Attributes

基本信息

别名： Lysine--tRNA Ligase;Lysyl-tRNA Synthetase;LysRS;KARS;KIAA0070
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 100mM NaCl, 1mM DTT, 20% Glycerol, pH 8.0.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

产品信息

背景说明： Lysine-tRNA ligase，also known as Lysyl-tRNA synthetase，LysRS，KARS and KIAA0070，belongs to the class-II aminoacyl-tRNA synthetase family.The N-terminal cytoplasmic domain (1-65) is a functional tRNA-binding domain，which is required for nuclear localization，is involved in the interaction with DARS，but has a repulsive role in the binding to EEF1A1.A central domain (208-259) is involved in homodimerization and is required for interaction with HIV-1 GAG and incorporation into virions.KARS catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.Defects in KARS are the cause of Charcot-Marie-Tooth disease recessive intermediate type B (CMTRIB).
来源： Human Cells

其它标识

内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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注意事项 Considerations

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