Recombinant Human BLNK/BASH/ SLP65,BR

产品属性 Product Attributes

基本信息

别名： B-Cell Linker Protein;B-Cell Adapter Containing a SH2 Domain Protein;B-Cell Adapter Containing a Src Homology 2 Domain Protein;Cytoplasmic Adapter Protein;Src Homology 2 Domain-Containing Leukocyte Protein of 65 kDa;SLP-65;BLNK;BASH;SLP65
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： B-Cell Linker Protein (BLNK) is a cell membrane protein which contains 1 SH2 domain.BLNK is expressed in B cells and fibroblast cell lines，playing a important role in B cell receptor signaling.BLNK as a central linker protein，downstream of the B-cell receptor (BCR)，bridges the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development.BLNK associates with the activation of ERK/EPHB2，MAP kinase p38 and JNK，modulates AP1，NF-kappa-B and NFAT activation.BLNK involves in BCR-mediated PLCG1 and PLCG2 activation and Ca2+ mobilization and is required for trafficking of the BCR to late endosomes.BLNK deficiency results in agammaglobulinemia type 4 and much more profound block in B-cell development.
来源： E.coli

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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