Recombinant Human MERTK/MER/Receptor tyrosine kinase MerTK,BR

产品属性 Product Attributes

基本信息

别名： Tyrosine-protein kinase Mer/Proto-oncogene c-Mer/Receptor tyrosine kinase MerTK/MERTK/MER
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM Tris,150mM NaCl,pH8.0.
纯度: ≥90% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Tyrosine-protein kinase Mer (MERTK) is a single-pass type I membrane protein which belongs to the MER/AXL/TYRO3 receptor kinase family.MERTK include two fibronectin type-III domains，two Ig-like C2-type domains，and one tyrosine kinase domain.It can’t be expressed in normal B- and T-lymphocytes，but it is usually expressed in numerous neoplastic B- and T-cell lines.MERTK could regulate many physiological processes，such as cell survival，migration，differentiation.It was demonstrated that the MERTK plays critical role in the engulfment and efficient clearance of apoptotic cells，platelet aggregation，and cytoskeleton reorganization.Not only these，it also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1，which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.In addition，MERTK could regulate rod outer segments fragments phagocytosis in the retinal pigment epithelium (RPE)，deficiency in MERTK are the cause of retinitis pigmentosa.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.Immobilized Human CADM1-Fc(Cat#C759)at 2μg/ml(100 μl/well)can bind Human CRTAMV-His(Cat#C331).The ED50 of Human CRTAMV-His(Cat#C331)is 4.905 ug/ml.

产品介绍 Product Introduction

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