Recombinant Mouse IL-1RA/IL-1RN/Interleukin-1 Receptor Antagonist Protein,BR

产品属性 Product Attributes

基本信息

别名： IL-1RN;IL-1ra;IRAP;IL1 inhibitor;Il1rn;Interleukin-1 Receptor Antagonist Protein
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Interleukin-1 receptor antagonist protein (Il1rn)，also known as IL-1ra，IRAP or IL1 inhibitor，is a member of the interleukin 1 cytokine family.This protein inhibits the activities of interleukin 1 alpha (IL1A) and interleukin 1 beta (IL1B)，and modulates a variety of interleukin 1 related immune and inflammatory responses.The mouse Il1rn gene encodes a 178 amino acids (aa) protein with a 26 aa signal peptide.Mouse Il1rn protein shares 26% and 19% identity with its homologues IL-1 beta and IL-1 alpha，respectively.Il1rn can Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling，but has no interleukin-1 like activity.Recently，an recombinant human Il1rn protein is used in the treatment of rheumatoid arthritis，an autoimmune disease in which IL-1 plays a key role.
来源： E.coli

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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