Recombinant Rat IL-12/Interleukin-12,BR

产品属性 Product Attributes

基本信息

别名： Interleukin-12;IL-12
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Interleukin 12 (IL-12) is the founding member of the IL-12 family of heterodimeric cytokines，which have important immunological functions.IL-12 is composed of two disulfide-linkedsubunits of 35 kDa and 40 kDa，respectively.The 35 kDa subunit (p35) is an α-helical protein homologous to IL-6 and GCSF.The 40 kDa subunit(p40) contains one fibronectin type III and one Ig C2-like domain，and has a high degree of structural homology to type I cytokine receptors.Whereas p35 subunit is unique to IL-12，the p40 subunit is also utilized in IL-23.Mature rat p35 is a 194 amino acids (aa) protein that is secreted as a heterodimer linked to p40.It contains three potential N-linked glycosylation sites and shares 86%，and 58% aa sequence identity with mouse and human p35，respectively.Mature rat p40 contains 313 aa and can exist in multiple forms，including monomer，homodimer，heterodimer linked to p19 (forming IL23)，and heterodimer linked to p35 (forming IL-12).IL12 facilitates hematopoietic stem cell proliferation，induces NK cell proliferation，and potentiates the expansion and late activation of Th1 CD4+ T cells.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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