Recombinant Mouse Sclerostin/SOST,BR

产品属性 Product Attributes

基本信息

别名： Sclerostin;Sost
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Sclerostin (SOST) is a member of the cerberus/DAN family，a group of secreted glycoproteins characterized by a cysteine-knotmotif.Cerberus/DANfamily members are putative BMP antagonists，and include Dan，Cerberus，Gremlin，PRDC，and Caronte.While the overall sequence identity between members of the family is low，they have conserved spacing of six cysteine residues.Cerberus and Dan have an additional cysteine residue used for dimerization however，SOST does not and is secreted as a monomer.SOST was originally identified as an important regulator of bone homeostasis.SOST is expressed by osteoclasts in developing bones of mouse embryos，includingboth intramembranously forming skull bones and endochondrally forming long bones.SOST plays a physiological role as a negative regulator of bone formation by repressing BMP-inducedosteogenesis.SOST has been shown to have unique ligand specificity，binding BMP-5，-6，and -7 with high affinity and BMP-2 and -4 with low affinity.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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