Recombinant Human MMP-8/Matrix metalloproteinase-8,BR

产品属性 Product Attributes

基本信息

别名： Neutrophil collagenase;Matrix metalloproteinase-8;MMP-8;PMNL collagenase;PMNL-CL;MMP8;CLG1
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.Note: The proenzyme needs to be activated by APMA.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Matrix metalloproteinases (MMPs) are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix.MMP8 (neutrophil collagenase) is expressed in neutrophils，where it is stored in specific granules.MMP8 release from the neutrophils is stimulated by various factors such as interleukins 1 and 8，TNF-α and GM-CSF.MMP8 is capable of cleaving types I，II and III triple-helical collagen，gelatin peptides，fibronectin，proteoglycans，aggrecan，serpins，β-casein and peptides such as angiotensin and substance P.In addition to its function in phagocytosis，MMP8 has a high capacity for infiltrating connective tissue，and is implicated in the breakdown of the extracellular matrix in diseases such as rheumatoid arthritis.Structurally，MMP8 consists of several domains: a pro-domain that is cleaved upon activation，a catalytic domain containing the zinc-binding site，a short hinge region and a hemopexin-like domain.MMP8 is heavily glycosylated.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein indistilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/μg(1 EU/μg)as determined by LAL test.

产品介绍 Product Introduction

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