Recombinant Human PDCD8/AIF/AIFM1,BR

产品属性 Product Attributes

基本信息

别名： Apoptosis-Inducing Factor 1 Mitochondrial;Programmed Cell Death Protein 8;AIFM1;AIF;PDCD8
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

产品信息

背景说明： Apoptosis-Inducing Factor 1，Mitochondrial (AIFM1) is a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells.During apoptosis，it is translocated from the mitochondria to the nucleus to function as a proapoptotic factor in a caspase-independent pathway，while in normal mitochondria，it functions as an antiapoptotic factor via its oxidoreductase activity.The soluble form (AIFsol) found in the nucleus induces parthanatos i.e.，caspase-independent fragmentation of chromosomal DNA.AIFM1 interacts with EIF3G，and thereby inhibits the EIF3 machinery and protein synthesis，and activates casapse-7 to amplify apoptosis.It binds to DNA in a sequence-independent manner and plays a critical role in caspase-independent，pyknotic cell death in hydrogen peroxide-exposed cells.
来源： E.coli

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

暂无数据

注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。