Recombinant Human Amyloid Precursor,BR

产品属性 Product Attributes

基本信息

别名： Amyloid Precursor;Amyloid Precursor Protein 695;APP695
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Amyloid precursor protein (APP) is a type I membrane protein with several isoforms due to alternative splicing，performs physiological functions on the surface of neurons relevant to neurite growth，neuronal adhesion and axonogenesis.Of the three major splice isoforms of APP (APP695，APP751，and APP770) APP695 is the predominant neuronal form from which Amyloid beta peptide and transcriptionally-active cleaved intracellular domain of APP (AICD) are preferentially generated by selective processing through the amyloidogenic pathway.Human APP695 consists of a 17 amino acid (aa) signal sequence，a 607 aa extracellular domain (ECD)，a 24 aa transmembrane domain，and a 47 aa cytoplasmic domain.Within the ECD，human APP695 shares 97% aa sequence identity with mouse and rat APP695.Amyloid beta is a major molecule implicated in pathogenesis of Alzheimer's disease (AD) and related dementias.AICD regulates expression by direct promoter binding of multiple genes，including APP itself，the beta-secretase，BACE-1 and the Amyloid beta-degrading enzyme，Neprilysin.As such，APP695 plays an important role in brain development，learning and memory，synaptic plasticity，and neurodegeneration including AD.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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