Recombinant Human Cystatin E/Cystatin M/CST6,BR

产品属性 Product Attributes

基本信息

别名： Cystatin-M;Cystatin-6;Cystatin-E;CST6
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM MES, 150mM NaCl, pH 5.5.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Cystatin-M is a typical secretory protein.It is synthesized as a preprotein with a patent N-terminal signal sequence.It belongs to the cystatin family.The most widely accepted function of cystatins is that of protease inhibitors.Most cysteine proteases are confined within cells where optimal pH and redox conditions favor their enzymatic activity.Thus，the majority of intracellular cysteine proteases are inactivated by oxidizing conditions outside the cells.Among the various types of intracellular cysteine proteases，cystatins seem to target preferentially endosomal/lysosomal cysteine proteases of the papain family，such as cathepsin B，cathepsin K/O2，cathepsin L，cathepsin L2/V and cathepsin S.Another important function of Cst6 seems to be in the terminal differentiation of stratified squamous epithelial cells and in the formation of cornified envelops.Cst6 is believed to be important in fine-tuning the enzymatic activities of endosomal/lysosomal cysteine proteases such as cathepsin L，cathepsin L2/V and AEP/mammalian legumain.Deregulated activity of these proteases could lead to abnormal activation of transglutaminases and disorders in cornification.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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