Recombinant Human Serpin A1/a1-Antitrypsin,BR

产品属性 Product Attributes

基本信息

别名： Alpha-1-Antitrypsin;Alpha-1 Protease Inhibitor;Alpha-1-Antiproteinase;Serpin A1;SERPINA1;AAT;PI
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, 2mM CaCl2, pH 7.5.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Serpin A1 is a prototype member of the Serpin superfamily of the serine protease inhibitors.As one of the most abundant proteinase inhibitors in the circulation，it is synthesized in hepatocytes，and to a lesser extent，in macrophages as well as intestinal epithelial cell lines and secreted as the abundant proteinase inhibitor in the circulation whose targets include elastase，plasmin，thrombin，trypsin，chymotrypsin，and plasminogen activator.Point mutations in the native SerpinA1 variants result in Serpin A1 deficiency，and consequently lead to several clinical complications such as pulmonary emphysema，juvenile hepatitis，cirrhosis，and hepatocellular carcinoma.For example，the Z variants (Glu342 to Lys) forms intracellular inclusion bodies，is not secreted，and leads to a severe SerpinA1 deficiency.Accordingly，Serpin A1 deficiency in circulation is associated with emphysema or liver disease.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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