Recombinant Mouse IL-13(Pro22-Phe131),BR

Known as:Interleukin-13; IL-13; T-Cell Activation Protein P600; Il13; Il-13
Derived from:E.coli
Purity:Greater than 95% as determined by reducing SDS-PAGE.
Formulation:Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
Storage:Lyophilized protein should be stored at < -20°c,="" though="" stable="" at="" room="" temperature="" for="" 3="" weeks.reconstituted="" protein="" solution="" can="" be="" stored="" at="" 4-7°c="" for="" 2-7="" days.aliquots="" of="" reconstituted="" samples="" are="" stable="" at="">< -20°c="" for="" 3="">
Reconstitution:Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Endotoxin:Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.
Background:Mouse interleukin 13 (mIL-13) is a pleiotropic cytokine produced by activated Th2 cells. IL-13 induces B cell proliferation and immunoglobin production. It contains a four helical bundle with two internal disulfide bonds. Mouse IL13 shares 58% sequence identity with human protein and exhibits cross-species activity. IL13 signals via receptor IL13R (type2, IL4R) and activates STAT-6. IL13 initially binds IL-13Rα1 with low affinity and triggers association of IL4Rα, generating a high affinity heterodimeric receptor IL13R and eliciting downstream signals. IL13 also binds IL-13Rα2 with high affinity, which plays a role in a negative feedback system of IL13 signaling. IL13 is an important mediator of allergic inflammation and disease.
规格:10ug, 50ug, 500ug, 1mg, 注意：
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