Recombinant Mouse Mcpt6/Mast Cell Protease-6/mMCP-6/Tpsb2/Tryptase beta-2,BR

产品属性 Product Attributes

基本信息

别名： Tryptase beta-2;Tryptase-2;Mast cell protease 6;mMCP-6
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Supplied as a 0.2 μm filtered solution of PBS, 1mM EDTA, pH 8.0.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

产品信息

背景说明： Tryptase beta-2(Tpsb2)，also known as Mast cell protease 6(mMCP-6)，belongs to the peptidase S1 family and Tryptase subfamily.Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.It plays a role in innate immunity.Tpsb2 can be detected primarily in skin during embryogenesis.Tpsb2 can not be detected at early embryonic stages but is abundantly expressed in later stages with a peak at E17.5-E18.5.Tryptase is a homotetramer.The active tetramer is converted to inactive monomers at neutral and acidic pH in the absence of heparin.Low concentrations of inactive monomers become active monomers at pH 6.0 in the presence of heparin.When the concentration of active monomers is higher，they convert to active monomers and then to active tetramers.These monomers are active and functionally distinct from the tetrameric enzyme.In contrast to the hidden active sites in the tetrameric form，the active site of the monomeric form is accessible for macromolecular proteins and inhibitors eg: fibrinogen which is a substrate for the monomeric but not for the tetrameric form.The monomeric form forms a complex with SERPINB6.
来源： Human Cells

其它标识

内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
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3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。