Recombin human CDKN1A/P21 protein,BR

产品属性 Product Attributes

基本信息

基因名: CDKN1A/P21
别名: CAP20，CDK interacting protein 1，CDKN1，CDKN1A，CIP1，MDA 6，MDA6，P21，p21CIP1，PIC1，SDI1，WAF1
全名: Cyclin-dependent kinase inhibitor 1A
英文名称: Recombinant human CDKN1A/P21 protein
中文名称: 周期蛋白依赖激酶抑制剂1A
规格: 10ug ; 50ug ; 100ug ; 1mg
外观:(性状) Liquid: Supplied as a 0.2 μm filtered solution of 20mM Tris, 0.5M NaCl, 10% Gly, pH8.0.
纯度: ≥85% by SDS-PAGE.
储存条件: Reconstituted protein solution can be stored at < -70°C for 6 months.Please minimize freeze-thaw cycles.
运输条件: The product is shipped on dry ice.Upon receipt, store it immediately at the temperature listed below.
浓度: 1mg/ml by SDS-PAGE.

产品信息

Swiss Prot： P38936
Gene ID： 1026
交叉反应： Human Mouse
分子量： 18kDa
区间范围： 1-164aa
背景说明： This gene encodes a potent cyclin-dependent kinase inhibitor.The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1.The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli.This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair.This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation.Mice that lack this gene have the ability to regenerate damaged or missing tissue.Multiple alternatively spliced variants have been found for this gene.
应用： Immunology research
来源： E.coli

其它标识

纯化方法： NI-NTA affinity purification
溶剂： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.)
内毒素： Not measured
生物活性： N0
标签信息： With a 6×His tag at the N/C-terminus.

产品介绍 Product Introduction

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注意事项 Considerations

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