Recombin human KHDRBS3 protein,BR

产品属性 Product Attributes

基本信息

基因名: KHDRBS3
别名: KHDRBS3;Etle;SALP;SLM-2;SLM2;T-STAR;TSTAR;etoile;
全名: KH domain containing，RNA binding，signal transduction associated 3
英文名称: Recombinant human KHDRBS3 protein
中文名称: KH结构域,RNA结合,信号转导相关蛋白3
规格: 10ug ; 50ug ; 100ug ; 1mg
外观:(性状) Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. (Or liquid with 5% glycerol.)
纯度: ≥85% by SDS-PAGE.
储存条件: Reconstituted protein solution can be stored at 4-7°C for 1-2 weeks, stored at < -20°C for 1 year.
运输条件: The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below.
浓度: 1mg/ml by SDS-PAGE.

产品信息

Swiss Prot： O75525
Gene ID： 10656
交叉反应： Human Mouse Rat
分子量： 39kDa
区间范围： 1-346aa
背景说明： RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion.Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro.Binds optimally to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides.Binds poly(A).RNA-binding abilities are down-regulated by tyrosine kinase PTK6 (PubMed:10564820, PubMed:19561594, PubMed:26758068).Involved in splice site selection of vascular endothelial growth factor (PubMed:15901763).In vitro regulates CD44 alternative splicing by direct binding to purine-rich exonic enhancer (By similarity).Can regulate alternative splicing of neurexins NRXN1-3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners such as neuroligins and LRRTM family members (PubMed:26758068).Targeted, cell-type specific splicing regulation of NRXN1 at AS4 is involved in neuronal glutamatergic synapse function and plasticity (By similarity).May regulate expression of KHDRBS2/SLIM-1 in defined brain neuron populations by modifying its alternative splicing (By similarity).Can bind FABP9 mRNA (By similarity).May play a role as a negative regulator of cell growth.Inhibits cell proliferation.
应用： Immunology research
来源： E.coli

其它标识

纯化方法： NI-NTA affinity purification
溶剂： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.)
内毒素： Not measured
生物活性： N0
标签信息： With a 6×His tag at the N/C-terminus.

产品介绍 Product Introduction

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