Recombin human LIG4 protein,BR

产品属性 Product Attributes

基本信息

基因名: LIG4
别名: DNA ligase 4，DNA ligase IV，LIG4，ligase IV，DNA，ATP dependent
全名: DNA ligase 4
英文名称: Recombinant human LIG4 protein
中文名称: DNA连接酶4
规格: 10ug ; 50ug ; 100ug ; 1mg
外观:(性状) Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. (Or liquid with 5% glycerol.)
纯度: ≥85% by SDS-PAGE.
储存条件: Reconstituted protein solution can be stored at 4-7°C for 1-2 weeks, stored at < -20°C for 1 year.
运输条件: The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below.
浓度: 1mg/ml by SDS-PAGE.

产品信息

Swiss Prot： P49917
Gene ID： 3981
交叉反应： Human Mouse (Chicken)
分子量： 38kDa
区间范围： 562-911aa
背景说明： The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction.This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ).This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK).Both XRCC4 and DNA-PK are known to be required for NHEJ.The crystal structure of the complex formed by this protein and XRCC4 has been resolved.Defects in this gene are the cause of LIG4 syndrome.Alternatively spliced transcript variants encoding the same protein have been observed.
应用： Immunology research
来源： E.coli

其它标识

纯化方法： NI-NTA affinity purification
溶剂： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.)
内毒素： Not measured
生物活性： N0
标签信息： With a 6×His tag at the N/C-terminus.

产品介绍 Product Introduction

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