Recombin human CDKN2B protein,BR

基因名:CDKN2B
英文全称:cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
别称:CDK4I, INK4B, MTS2, P15, p15INK4b, TP15
中文名称:周期素依赖性激酶抑制因子2B
Uniprot:P42772
GeneID:1030
交叉反应(推测):Human Mouse Rat (Bovine)
氨基酸大小:15kDa
表达氨基酸:1-138aa
Background:This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors.This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression.The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition.Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.
Application:Immunology research
Derived from:E.coli
Purification:NI-NTA affinity purification
Formulation:Lyophilized from a 0.2 μm filtered solution of Tris-HCl, PH8.0.
Shipping:The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below.
Storage:Reconstituted protein solution can be stored at 4-7°C for 1-2 months, stable at < -20°c="" for="" 2-3="">
Reconstitution:Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Purity:Purity≥85% as determined by reducing SDS-PAGE.
规格:10ug, 50ug, 100ug, 1mg, 注意：
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