Recombin human CHCHD2 protein,BR

基因名:CHCHD2
英文全称:coiled-coil-helix-coiled-coil-helix domain containing 2
别称:CHCHD2; C7orf17; MNRR1; NS2TP; PARK22; coiled-coil-helix-coiled-coil-helix domain containing 2
中文名称:含coiled-coil-helix结构域蛋白2
Uniprot:Q9Y6H1
GeneID:51142
交叉反应(推测):Human Mouse
氨基酸大小:16kDa
表达氨基酸:1-152aa
Background:The protein encoded by this gene belongs to a class of eukaryotic CX(9)C proteins characterized by four cysteine residues spaced ten amino acids apart from one another.These residues form disulfide linkages that define a CHCH fold.In response to stress, the protein translocates from the mitochondrial intermembrane space to the nucleus where it binds to a highly conserved 13 nucleotide oxygen responsive element in the promoter of cytochrome oxidase 4I2, a subunit of the terminal enzyme of the electron transport chain.In concert with recombination signal sequence-binding protein J, binding of this protein activates the oxygen responsive element at four percent oxygen.In addition, it has been shown that this protein is a negative regulator of mitochondria-mediated apoptosis.In response to apoptotic stimuli, mitochondrial levels of this protein decrease, allowing BCL2-associated X protein to oligomerize and activate the caspase cascade.Pseudogenes of this gene are found on multiple chromosomes.Alternative splicing results in multiple transcript variants.
Application:Immunology research
Derived from:E.coli
Purification:NI-NTA affinity purification
Formulation:Lyophilized from a 0.2 μm filtered solution of Tris-HCl, PH8.0.
Shipping:The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below.
Storage:Reconstituted protein solution can be stored at 4-7°C for 1-2 months, stable at < -20°c="" for="" 2-3="">
Reconstitution:Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Purity:Purity≥85% as determined by reducing SDS-PAGE.
规格:10ug, 50ug, 100ug, 1mg, 注意：
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