Recombin human TRPM8 protein,BR

产品属性 Product Attributes

基本信息

基因名: TRPM8
别名: TRPM8;LTRPC6;TRPP8;transient receptor potential cation channel subfamily M member 8
全名: transient receptor potential cation channel，subfamily M，member 8
英文名称: Recombinant human TRPM8 protein
中文名称: 瞬时受体电位阳离子通道M亚家族成员8
规格: 10ug ; 50ug ; 100ug ; 1mg
外观:(性状) Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. (Or liquid with 5% glycerol.)
纯度: ≥85% by SDS-PAGE.
储存条件: Reconstituted protein solution can be stored at 4-7°C for 1-2 weeks, stored at < -20°C for 1 year.
运输条件: The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below.
浓度: 1mg/ml by SDS-PAGE.

产品信息

Swiss Prot： Q7Z2W7
Gene ID： 79054
交叉反应： Human Mouse Rat
分子量： 23kDa
区间范围： 1-192aa
背景说明： Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius.Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH.Involved in menthol sensation.Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium.Temperature sensing is tightly linked to voltage-dependent gating.Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves.The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials.Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity.Plays a role in prostate cancer cell migration .Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel.
应用： Immunology research
来源： E.coli

其它标识

纯化方法： NI-NTA affinity purification
溶剂： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.)
内毒素： Not measured
生物活性： N0
标签信息： With a 6×His tag at the N/C-terminus.

产品介绍 Product Introduction

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注意事项 Considerations

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3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。