Recombin human RFFL protein,BR

产品属性 Product Attributes

基本信息

基因名: RFFL
别名: RFFL;CARP-2;CARP2;FRING;RIFIFYLIN;RNF189;RNF34L;E3 ubiquitin-protein ligase rififylin
全名: E3 ubiquitin-protein ligase rififylin
英文名称: Recombinant human RFFL protein
中文名称: E3泛素-蛋白连接酶rififylin
规格: 10ug ; 50ug ; 100ug ; 1mg
外观:(性状) Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. (Or liquid with 5% glycerol.)
纯度: ≥85% by SDS-PAGE.
储存条件: Reconstituted protein solution can be stored at 4-7°C for 1-2 weeks, stored at < -20°C for 1 year.
运输条件: The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below.
浓度: 1mg/ml by SDS-PAGE.

产品信息

Swiss Prot： Q8WZ73
Gene ID： 117584
交叉反应： Human Mouse Rat
分子量： 41kDa
区间范围： 1-363aa
背景说明： E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins.Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex.Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis.Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation.Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation.Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN.May also play a role in endocytic recycling.
应用： Immunology research
来源： E.coli

其它标识

纯化方法： NI-NTA affinity purification
溶剂： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.)
内毒素： Not measured
生物活性： N0
标签信息： With a 6×His tag at the N/C-terminus.

产品介绍 Product Introduction

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注意事项 Considerations

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