Recombin human CPEB3 protein,BR

基因名:CPEB3
英文全称:cytoplasmic polyadenylation element binding protein 3
别称:CPE-BP3;CPE-binding protein 3;hCPEB-3;KIAA0940
中文名称:胞质多聚腺苷酸化元件结合蛋白3
Uniprot:Q8NE35
GeneID:22849
交叉反应(推测):Human Mouse
氨基酸大小:39kDa
表达氨基酸:1-350aa
Background:Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator (By similarity).In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3'-UTR, but binds to a U-rich loop within a stem-loop structure (By similarity).Required for the consolidation and maintenance of hippocampal-based long term memory (By similarity).In the basal state, binds to the mRNA 3'-UTR of the glutamate receptors GRIA2/GLUR2 mRNA and negatively regulates their translation (By similarity).Also represses the translation of DLG4, GRIN1, GRIN2A and GRIN2B (By similarity).When activated, acts as a translational activator of GRIA1 and GRIA2 (By similarity).In the basal state, suppresses SUMO2 translation but activates it following neuronal stimulation (By similarity).Binds to the 3'-UTR of TRPV1 mRNA and represses TRPV1 translation which is required to maintain normal thermoception (By similarity).Binds actin mRNA, leading to actin translational repression in the basal state and to translational activation following neuronal stimulation (By similarity).Negatively regulates target mRNA levels by binding to TOB1 which recruits CNOT7/CAF1 to a ternary complex and this leads to target mRNA deadenylation and decay.In addition to its role in translation, binds to and inhibits the transcriptional activation activity of STAT5B without affecting its dimerization or DNA-binding activity.This, in turn, represses transcription of the STAT5B target gene EGFR which has been shown to play a role in enhancing learning and memory performance.In contrast to CPEB1, CPEB2 and CPEB4, not required for cell cycle progression.
Application:Immunology research
Derived from:E.coli
Purification:NI-NTA affinity purification
Formulation:Lyophilized from a 0.2 μm filtered solution of Tris-HCl, PH8.0.
Shipping:The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below.
Storage:Reconstituted protein solution can be stored at 4-7°C for 1-2 months, stable at < -20°c="" for="" 2-3="">
Reconstitution:Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Purity:Purity≥85% as determined by reducing SDS-PAGE.
Endotoxin:/
规格:10ug, 50ug, 100ug, 1mg, 注意：
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