Recombin human HIF1AN protein,BR

基因名:HIF1AN
英文全称:hypoxia inducible factor 1, alpha subunit inhibitor
别称:FIH1
中文名称:缺氧诱导因子1,α亚单位抑制剂
Uniprot:Q9NWT6
GeneID:55662
交叉反应(推测):Human Mouse Rat (Pig)
氨基酸大小:39kDa
表达氨基酸:1-350aa
Background:Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD).Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator.Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases.Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins.Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively.Negatively regulates NOTCH1 activity, accelerating myogenic differentiation.Positively regulates ASB4 activity, promoting vascular differentiation.
Application:Immunology research
Derived from:E.coli
Purification:NI-NTA affinity purification
Formulation:Lyophilized from a 0.2 μm filtered solution of Tris-HCl, PH8.0.
Shipping:The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below.
Storage:Reconstituted protein solution can be stored at 4-7°C for 1-2 months, stable at < -20°c="" for="" 2-3="">
Reconstitution:Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Purity:Purity≥85% as determined by reducing SDS-PAGE.
Endotoxin:/
规格:10ug, 50ug, 100ug, 1mg, 注意：
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