Recombin human CDK7 protein,BR

产品属性 Product Attributes

基本信息

基因名: CDK7
别名: CAK;CAK1;CDKN7;HumanCAK;MO15;STK1;p39MO15
英文名称: Recombinant human CDK7 protein
全名: cyclin-dependent kinase 7
中文名称: 细胞周期蛋白依赖激酶7
规格: 10ug ; 50ug ; 100ug ; 1mg
外观:(性状) Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. (Or liquid with 5% glycerol.)
纯度: ≥85% by SDS-PAGE.
储存条件: Reconstituted protein solution can be stored at 4-7°C for 1-2 weeks, stored at < -20°C for 1 year.
运输条件: The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below.
浓度: 1mg/ml by SDS-PAGE.

产品信息

Swiss Prot： P50613
Gene ID： 1022
交叉反应： Human Mouse Rat
分子量： 39kDa
区间范围： 1-347aa
背景说明： Serine/tHumanreonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription.Cyclin-dependent kinases (CDKs) are activated by tHumane binding to a cyclin and mediate tHumane progression tHumanrougHuman tHumane cell cycle.EacHuman different complex controls a specific transition between 2 subsequent pHumanases in tHumane cell cycle.Required for botHuman activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation).CDK7 is tHumane catalytic subunit of tHumane CDK-activating kinase (CAK) complex.PHumanospHumanorylates SPT5/SUPT5Human, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11.CAK activates tHumane cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by tHumanreonine pHumanospHumanorylation, tHumanus regulating cell cycle progression.CAK complexed to tHumane core-TFIIHuman basal transcription factor activates RNA polymerase II by serine pHumanospHumanorylation of tHumane repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from tHumane promoter and elongation of tHumane transcripts.PHumanospHumanorylation of POLR2A in complex witHuman DNA promotes transcription initiation by triggering dissociation from DNA.Its expression and activity are constant tHumanrougHumanout tHumane cell cycle.Upon DNA damage, triggers p53/TP53 activation by pHumanospHumanorylation, but is inactivated in turn by p53/TP53; tHumanis feedback loop may lead to an arrest of tHumane cell cycle and of tHumane transcription, Humanelping in cell recovery, or to apoptosis.Required for DNA-bound peptides-mediated transcription and cellular growtHuman inHumanibition.
应用： Immunology research
来源： E.coli

其它标识

纯化方法： NI-NTA affinity purification
溶剂： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.)
内毒素： Not measured
生物活性： N0
标签信息： With a 6×His tag at the N/C-terminus.

产品介绍 Product Introduction

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