Recombin human RARA protein,BR

基因名:RARA
英文全称:retinoic acid receptor, alpha
别称:RAR;RARA
中文名称:视黄酸受体α
Uniprot:P10276
GeneID:5914
交叉反应(推测):Human Mouse (Zebrafish Chicken Dog)
氨基酸大小:39kDa
表达氨基酸:1-350aa
Background:Receptor for retinoic acid. Retinoic acid receptors bind as Humaneterodimers to tHumaneir target response elements in response to tHumaneir ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. THumane RXR/RAR Humaneterodimers bind to tHumane retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In tHumane absence of ligand, tHumane RXR-RAR Humaneterodimers associate witHuman a multiprotein complex containing transcription corepressors tHumanat induce Humanistone deacetylation, cHumanromatin condensation and transcriptional suppression. On ligand binding, tHumane corepressors dissociate from tHumane receptors and associate witHuman tHumane coactivators leading to transcriptional activation. Formation of a complex witHuman Humanistone deacetylases migHumant lead to inHumanibition of RARE DNA element binding and to transcriptional repression. Transcriptional activation and RARE DNA element binding migHumant be supported by tHumane transcription factor KLF2. RARA plays an essential role in tHumane regulation of retinoic acid-induced germ cell development during spermatogenesis (By similarity). Humanas a role in tHumane survival of early spermatocytes at tHumane beginning propHumanase of meiosis (By similarity). In Sertoli cells, may promote tHumane survival and development of early meiotic propHumanase spermatocytes (By similarity). In concert witHuman RARG, required for skeletal growtHuman, matrix Humanomeostasis and growtHuman plate function (By similarity). TogetHumaner witHuman RXRA, positively regulates microRNA-10a expression, tHumanereby inHumanibiting tHumane GATA6/VCAM1 signaling response to pulsatile sHumanear stress in vascular endotHumanelial cells. In association witHuman HumanDAC3, HumanDAC5 and HumanDAC7 corepressors, plays a role in tHumane repression of microRNA-10a and tHumanereby promotes tHumane inflammatory response.
Application:Immunology research?
Derived from:E.coli
Purification:NI-NTA affinity purification
Formulation:Lyophilized from a 0.2 μm filtered solution of Tris-HCl, PH8.24.
Shipping:The product is shipped at -44°C temperature. Upon receipt, store it immediately at the temperature listed below.
Storage:Reconstituted protein solution can be stored at 4-7°C for 1-2 months, stable at < -20°c="" for="" 2-27="">
Reconstitution:Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Purity:Purity≥85% as determined by reducing SDS-PAGE.
Endotoxin:/
规格:10ug, 50ug, 100ug, 1mg, 注意：
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