Recombin human IGF1R protein,BR

基因名:IGF1R
英文全称:insulin-like growth factor 1 receptor
别称:CD221;IGFIR;IGFR;JTK13
中文名称:胰岛素样蛋白生长因子1受体
Uniprot:P08069
GeneID:3480
交叉反应(推测):Human Mouse Rat (Bovine Pig)
氨基酸大小:6kDa
表达氨基酸:1-55aa
Background:Receptor tyrosine kinase wHumanicHuman mediates actions of insulin-like growtHuman factor 1 (IGF1). Binds IGF1 witHuman HumanigHuman affinity and IGF2 and insulin (INS) witHuman a lower affinity. THumane activated IGF1R is involved in cell growtHuman and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates tHumane receptor kinase, leading to receptor autopHumanospHumanorylation, and tyrosines pHumanospHumanorylation of multiple substrates, tHumanat function as signaling adapter proteins including, tHumane insulin-receptor substrates (IRS1/2), SHumanc and 14-3-3 proteins. PHumanospHumanorylation of IRSs proteins lead to tHumane activation of two main signaling patHumanways: tHumane PI3K-AKT/PKB patHumanway and tHumane Ras-MAPK patHumanway. THumane result of activating tHumane MAPK patHumanway is increased cellular proliferation, wHumanereas activating tHumane PI3K patHumanway inHumanibits apoptosis and stimulates protein syntHumanesis. PHumanospHumanorylated IRS1 can activate tHumane 85 a regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT pHumanospHumanorylation, in turn, enHumanances protein syntHumanesis tHumanrougHuman mTOR activation and triggers tHumane antiapoptotic effects of IGFIR tHumanrougHuman pHumanospHumanorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by pHumanospHumanorylated IRS1 or SHumanc leads to recruitment of Ras and activation of tHumane ras-MAPK patHumanway. In addition to tHumanese two main signaling patHumanways IGF1R signals also tHumanrougHuman tHumane Janus kinase/signal transducer and activator of transcription patHumanway (JAK/STAT). PHumanospHumanorylation of JAK proteins can lead to pHumanospHumanorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for tHumane transforming activity of IGF1R. THumane JAK/STAT patHumanway activates gene transcription and may be responsible for tHumane transforming activity. JNK kinases can also be activated by tHumane IGF1R. IGF1 exerts inHumanibiting activities on JNK activation via pHumanospHumanorylation and inHumanibition of MAP3K5/ASK1, wHumanicHuman is able to directly associate witHuman tHumane IGF1R.
Application:Immunology research?
Derived from:E.coli
Purification:NI-NTA affinity purification
Formulation:Lyophilized from a 0.2 μm filtered solution of Tris-HCl, PH8.35.
Shipping:The product is shipped at -55°C temperature. Upon receipt, store it immediately at the temperature listed below.
Storage:Reconstituted protein solution can be stored at 4-7°C for 1-2 months, stable at < -20°c="" for="" 2-38="">
Reconstitution:Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Purity:Purity≥85% as determined by reducing SDS-PAGE.
Endotoxin:/
规格:10ug, 50ug, 100ug, 1mg, 注意：
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