Recombin human SKP2 protein,BR

产品属性 Product Attributes

基本信息

基因名: SKP2
别名: FBL1;FBXL1;FLB1;p45;p45skp2;F-box protein Skp;
全名: S-phase kinase-associated protein 2 (p45)
英文名称: Recombinant human SKP2 protein
中文名称: S期激酶相关蛋白2(p45)
规格: 10ug ; 50ug ; 100ug ; 1mg
外观:(性状) Liquid: Supplied as a 0.2 μm filtered solution of 20mM Tris, 20mM NaCl, 1mM EDTA, 10% Gly, pH8.0.
纯度: ≥85% by SDS-PAGE.
储存条件: Reconstituted protein solution can be stored at < -70°C for 6 months.Please minimize freeze-thaw cycles.
运输条件: The product is shipped on dry ice.Upon receipt, store it immediately at the temperature listed below.
浓度: 1mg/ml by SDS-PAGE.

产品信息

Swiss Prot： Q13309
Gene ID： 6502
交叉反应： Human Mouse
分子量： 40kDa
区间范围： 1-350aa
背景说明： Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration.Through the ubiquitin-mediated proteasomal degradation of hepatitis C virus non-structural protein 5A, has an antiviral activity towards that virus.
应用： Immunology research
来源： E.coli

其它标识

纯化方法： NI-NTA affinity purification
溶剂： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.)
内毒素： Not measured
生物活性： N0
标签信息： With a 6×His tag at the N/C-terminus.

产品介绍 Product Introduction

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注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。