Recombin human MAPK15 protein,BR

产品属性 Product Attributes

基本信息

基因名: MAPK15
别名: MAP kinase 15;MAPK 15;ERK-7;ERK-8;ERK8;ERK7;
英文名称: Recombinant human MAPK15 protein
全名: mitogen-activated protein kinase 15
中文名称: 丝裂原激活的蛋白激酶15
规格: 10ug ; 50ug ; 100ug ; 1mg
外观:(性状) Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. (Or liquid with 5% glycerol.)
纯度: ≥85% by SDS-PAGE.
储存条件: Reconstituted protein solution can be stored at 4-7°C for 1-2 weeks, stored at < -20°C for 1 year.
运输条件: The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below.
浓度: 1mg/ml by SDS-PAGE.

产品信息

Swiss Prot： Q8TD08
Gene ID： 225689
交叉反应： Human Mouse Rat
分子量： 31.1kDa
区间范围： 1-277aa
背景说明： Atypical MAPK protein that regulates several process such as autophagy，ciliogenesis，protein trafficking/secretion and genome integrity，in a kinase activity-dependent manner (PubMed:22948227，PubMed:24618899，PubMed:29021280，PubMed:21847093，PubMed:20733054).Controls both，basal and starvation-induced autophagy throught its interaction with GABARAP，MAP1LC3B and GABARAPL1 leading to autophagosome formation，SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227).Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure，transport，and signaling (PubMed:29021280).Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum，thereby restricting the production of sugar-coated proteins (PubMed:24618899).Upon amino-acid starvation，mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PubMed:21847093).Binds to chromatin leading to MAPK15 activation and interaction with PCNA，that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA (PubMed:20733054).Regulates DA transporter (DAT) activity and protein expression via activation of RhoA (PubMed:28842414).In response to H2O2 treatment phosphorylates ELAVL1，thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (PubMed:26595526).Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity).Phosphorylates in vitro FOS and MBP (PubMed:11875070，PubMed:16484222，PubMed:20638370，PubMed:19166846).During oocyte maturation，plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes，fertilized eggs，and early embryos (By similarity).Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (PubMed:21190936).
应用： Immunology research
来源： E.coli

其它标识

纯化方法： NI-NTA affinity purification
溶剂： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.)
内毒素： Not measured
生物活性： N0
标签信息： With a 6×His tag at the N/C-terminus.

产品介绍 Product Introduction

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