TP-0903游离态一种高效性的、选择性的Axl受体酪氨酸激酶抑制剂,IC50:27nM。Dubermatinib is a potent and selective AXL inhibitor. TP-0903 induces massive apoptosis in CLL B cells with LD50 values of nanomolar ranges. Combination of TP-0903 with BTK inhibitors augments CLL B-cell apopto