Astragalus polysaccharide 黄芪多糖,UV≥90%

产品属性 Product Attributes

基本信息

中文名称: 黄芪多糖
英文名称: Astragalus Polysaccharide
别名： Astragalus Polysacharin

分子式: Mixture
规格: 50mg ; 100mg
溶解性： Soluble in Water ≥5mg/mL(可能有少量杂质不溶，但并不影响使用/There may be a small amount of impurities that do not dissolve, but it does not affect the use )
纯度： UV≥90%
级别： Cell Culture
外观(性状): White to yellow Solid
储存条件: Powder: 2-8℃，2 years
运输条件: 冷藏运输

生物活性 以下数据均来自公开文献, ACMEC暂未进行独立验证, 仅供参考。
背景说明:

由己糖醛酸、葡萄糖、果糖、鼠李糖、阿拉伯糖、半乳糖醛酸和葡萄糖醛酸等组成,可作为免疫促进剂或调节剂,同时具有抗病毒、抗肿瘤、抗衰老、抗辐射、抗应激、抗氧化等作用。

生物活性:

APS can protect the cytotoxicity and genotoxicity of human BMSCs induced by FA. The mechanism may be associated with up-regulated expression of XPA, XPC, ERCC1, RPA1, and RPA2 in the nucleotide excision repair (NER) pathway which promotes DNA damage repair.[1]

In Vitro:

Human BMSCs were cultured in vitro and randomly divided into control cells(Ctrl group)，FA-treated cells(FA group，120 μmol/L)，and cells incubated with FA and increasing concentrations(40，100，or 400 μg/mL)of APS(FA + APS groups). Compared with the FA group，the cytotoxicity，DNA strand breakage，DPCs，and micronucleus levels were decreased significantly in FA + APS groups(P < 0.01). Meanwhile，the mRNA and protein expression of XPA，XPC，ERCC1，RPA1，and RPA2 were up regulated significantly in the FA + APS groups(P < 0.05)with the most prominent effect of the 100 μg/mL APS.[1]

数据来源文献 [1] She Y, Zhao X, Wu P, Xue L, Liu Z, Zhu M, Yang J, Li Y. Astragalus polysaccharide protects formaldehyde-induced toxicity by promoting NER pathway in bone marrow mesenchymal stem cells. Folia Histochem Cytobiol. 2021;59（2）:124-133.

产品介绍 Product Introduction

由己糖醛酸、葡萄糖、果糖、鼠李糖、阿拉伯糖、半乳糖醛酸和葡萄糖醛酸等组成，可作为免疫促进剂或调节剂，同时具有抗病毒、抗肿瘤、抗衰老、抗辐射、抗应激、抗氧化等作用。

使用本产品的案例（仅供参考）

In Vitro

Cell（Human BMSCs ,40~400 μg/mL APS, 24h）

BMSCs were randomly divided into control group, FA group, and FA + APS 40, 100 and 400 μg/mL groups. In the control group, the cells were cultured with D-MEM/F-12. The cells in the FA group were cultured with 120 μmol/L FA of D-MEM/F-12. BMSCs co-cultured with 120 μmol/L FA and 40, 100, 400 μg/mL APS of D-MEM/F-12 served as FA + APS 40, 100 and 400 μg/mL groups. FA and APS were added at the same time and incubated together with BMSCs for 24 h.

来源文献：She Y, Zhao X, Wu P, Xue L, Liu Z, Zhu M, Yang J, Li Y. Astragalus polysaccharide protects formaldehyde-induced toxicity by promoting NER pathway in bone marrow mesenchymal stem cells. Folia Histochem Cytobiol. 2021;59（2）:124-133. doi: 10.5603/FHC.a2021.0013. Epub 2021 May 19. PMID: 34008856.

Cell（The Caco-2 cells，treated with different concentrations of APS for 24 h）

For treatment, the cells were stimulated with 1 μg/ml-1 of lipopolysaccharide (LPS; AC12037, ACMEC) for 24 h and then treated with different concentrations of APS (AC11971, ACMEC) for 24 h.

来源文献：Ying Y, Song LY, Pang WL, Zhang SQ, Yu JZ, Liang PT, Li TG, Sun Y, Wang YY, Yan JY, Yang ZS. Astragalus polysaccharide protects experimental colitis through an aryl hydrocarbon receptor-dependent autophagy mechanism. Br J Pharmacol. 2024 Mar;181（5）:681-697. doi: 10.1111/bph.16229. Epub 2023 Oct 12. PMID: 37653584.

注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。