Recombinant Human B7-H1/PD-L1,BR

产品属性 Product Attributes

基本信息

别名： Programmed Cell Death 1 Ligand 1;PD-L1;PDCD1 Ligand 1;Programmed Death Ligand 1;B7 Homolog 1;B7-H1;CD274;B7H1;PDCD1L1;PDCD1LG1;PDL1
英文名称： Recombinant Human B7-H1/PD-L1
中文名称： 重组人B7-H1/PD-L1
规格： 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 5% Trehalose, pH 7.4.
纯度： ≥95% as determined by reducing SDS-PAGE.
储存条件： Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
运输条件： 冷藏运输

产品信息

背景说明： CD274，also known as B7-H1 or programmed death ligand 1 (PD-L1)，is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily.Programmed death-1 ligand-1 (PD-L1，CD274，B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance.By binding to PD1 on activated T-cells and B-cells，PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression.Accordingly，it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers.PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.
来源： Human cells

其它标识

溶剂： Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in ddH2O.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素： Less than 0.1 ng/ug(1 IEU/ug)as determined by LAL test.

产品介绍 Product Introduction

Recombinant Human Programmed Cell Death 1 Ligand 1 is produced by our Mammalian expression system and the target gene encoding Phe19-Thr239 is expressed with a 6His tag at the C-terminus.

注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。