Recombinant Human SP-D/Pulmonary surfactant-associated protein D,BR

产品属性 Product Attributes

基本信息

别名： Pulmonary Surfactant-Associated Protein D;PSP-D;SP-D;Collectin-7;Lung Surfactant Protein D;SFTPD;COLEC7;PSPD;SFTP4
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
运输条件： The product is shipped at ambient temperature.

产品信息

背景说明： Surfactant Pulmonary-Associated Protein D (SP-D) is a 43 kDa member of the collectin family of innate immune modulators.Its principal components consist of a collagen-like region and a C-terminal carbohydrate recognition domain (CRD)，a structure that places it in a subset of pattern recognition proteins termed defense collagens.SP-D is constitutively secreted by alveolar lining cells and epithelium associated with tubular structures and induced in cardiac smooth muscle and endothelial cells.It binds both secreted and transmembrane proteins that transduce its function.It binds human neutrophil defensins，modulating influenza anti-viral defense.It binds MD-2/LY96，a secreted protein that cooperates with Toll-like receptors (TLRs) in the response of macrophages to bacterial lipopolysaccharides (LPS) or cell wall components.It also binds macrophage CD14 and TLRs directly，blocking binding of LPS and down-regulating TNF-α secretion.SP-D binding of both SIRPα and the calreticulin/CD91 complex on macrophages allows for a graded response to environmental challenge.
来源： Human cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in ddH2O.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 IEU/ug)as determined by LAL test.

产品介绍 Product Introduction

Recombinant Human Pulmonary Surfactant-Associated Protein D is produced by our Mammalian expression system and the target gene encoding Ala21-Phe375(Glu22Gly)? is expressed with a 6His tag at the C-terminus.

注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。