Recombinant Human Cytotoxic T-lymphocyte protein 4/CTLA4/CD152(Fc fusion),BR

产品属性 Product Attributes

基本信息

别名： Cytotoxic T-lymphocyte protein 4;Cytotoxic T-lymphocyte-associated antigen 4;CTLA4;CD152
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
运输条件： The product is shipped at ambient temperature.

产品信息

背景说明： Cytotoxic Tlymphocyte 4(CTLA-4，CD152)，is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily.Human or mouse CTLA4 cDNA encodes 223 amino acids (aa) including a 35 aa signal sequence，a 126 aa extracellular domain (ECD) with one Ig-like V-type domain，a 21 aa transmembrane (TM) sequence，and a 41 aa cytoplasmic sequence.It is widely expressed with highest levels in lymphoid tissues.CD28 and CTLA-4，together with their ligands，B7-1 and B7-2，constitute one of the dominant costimulatory pathways that regulate T and B cell responses.CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily.CTLA4 transmits an inhibitory signal to T cells，whereas CD28 transmits a stimulatory signal.Intracellular CTLA4 is also found in regulatory T Cells and may play an important role in their functions.Tcell activation through the Tcell receptor and CD28 leads to increased expression of CTLA4.
来源： Human cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in ddH2O.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 IEU/ug)as determined by LAL test.

产品介绍 Product Introduction

Recombinant Human Cytotoxic T-lymphocyte protein 4 is produced by our Mammalian expression system and the target gene encoding Lys36-Asp161 is expressed with a Fc tag at the C-terminus.

注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。