Recombinant Human TIGIT/VSTM3,BR

产品属性 Product Attributes

基本信息

别名： T-cell immunoreceptor with Ig and ITIM domains;;VSIG9;VSTM3;TIGIT;V-set and transmembrane domain-containing protein 3;V-set and immunoglobulin domain-containing protein 9
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
运输条件： The product is shipped at ambient temperature.

产品信息

背景说明： T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the CD28 family within the Ig superfamily of proteins.TIGIT is expressed on NK cells and subsets of activated，memory and regulatory T cells，and particularly on follicular helper T cells within secondary lymphoid organs.It binds to CD155 and Nectin-2 that appear on dendritic cells (DC) and endothelium.Ligation of TIGIT on T cells down-regulates TCR-mediated activation and subsequent proliferation，while NK cell TIGIT ligation blocks NK cell cytotoxicity.Through CD155 and Nectin-2，which also interact with DNAM-1/CD226 and CD96/Tactile，TIGIT is part of an interacting network of Ig superfamily members that may augment or oppose each other.In particular，TIGIT binding to CD155 can antagonize the effects of DNAM1.
来源： Human cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in ddH2O.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 IEU/ug)as determined by LAL test.

产品介绍 Product Introduction

Recombinant Human T cell Immunoreceptor with Ig and ITIM domains is produced by our Mammalian expression system and the target gene encoding Met22-Pro141 is expressed with a 6His tag at the C-terminus.

注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。