Recombinant Human TRANCE/RANK L/TNFSF11/CD254,BR

产品属性 Product Attributes

基本信息

别名： CD254;ODF;OPGL;RANK L;TNFSF11;CD254;Osteoclast differentiation factor;Receptor activator of nuclear factor kappa-B ligand;tumor necrosis factor ligand superfamily member 11
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM Tris,150mM NaCl,pH8.0.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
运输条件： The product is shipped at ambient temperature.

产品信息

背景说明： CD254，also known as RANKL，TNFSF11，TRANCE，OPGL and ODF，is a type II membrane protein of the tumor necrosis factor (TNF) superfamily，and affects the immune system and control bone regeneration and remodeling.RANKL is the ligand of nuclear factor (NF)-κB (RANK).When RANKL binds to RANK，it will undergo trimerization and then bind to an adaptor molecule TNF receptor-associated factor 6 (TRAF6).This results in the activation of several downstream signaling cascades，including the NFκB，mitogen-activated protein kinases (MAPK)，activating protein 1 (AP-1)，and nuclear factor of activated T cells (NFATc1)，resulting in the formation of multinucleated bone-resorbing osteoclasts.RANKL is widely expressed in skeletal muscle，thymus，liver，colon，small intestine，adrenal gland，osteoblast，mammary gland epithelial cells，prostate and pancreas.
来源： E.coli

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in ddH2O.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 IEU/ug)as determined by LAL test.

产品介绍 Product Introduction

Recombinant Human Receptor Activator of NF-kappa-B ligand is produced by our E.coli expression system and the target gene encoding Ile140-Asp317 is expressed with a 6His tag at the N-terminus.

注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。