小鼠骨形态发生蛋白7检测试剂盒,BR

产品属性 Product Attributes

基本信息

中文名称： 小鼠骨形态发生蛋白7检测试剂盒
英文名称： Mouse BMP7 ELISA Kit
别名： BMP-7; bone moorphogenic protein-7; bone morphogenetic protein 7 (osteogenic protein 1); bone morphogenetic protein 7 preproprotein; Eptotermin alfa; OP-1; Osteogenic protein 1
储存条件： 2-8℃，6 months
规格： 96T ; 48T
检测目标： BMP7
样品类型： 血清/血浆/细胞培养上清
反应性： Mouse
应用： ELISA
定量/定性： 定量检测
检测范围： 43.75-2800pg/mL
灵敏度： 21.875pg/mL
精密度： 板内，板间变异系数均<10%
回收率： 80%-120%
反应时间： 3h15min

Elisa信息

Swiss Prot： P23359
Gene ID： 12162
背景说明： Bone morphogenetic protein 7 (BMP7, also known as osteogenic protein-1 or OP-1) is a protein that in humans is encoded by the BMP7 gene[1] and belong to BMP family and the TGF-β superfamily. Like other members of the BMP family of proteins, it plays a key role in the transformation of mesenchymal cells into bone and cartilage. It is inhibited by noggin and a similar protein, chordin, which are expressed in the Spemann-Mangold Organizer. BMP7 may be involved in bone homeostasis. It is expressed in the brain, kidneys and bladder. [2] BMP7 induces the phosphorylation of SMAD1 and SMAD5, which in turn induce transcription of numerous osteogenic genes.[3] It has been demonstrated that BMP7 treatment is sufficient to induce all of the genetic markers of osteoblast differentiation in many cell types.[2] Human recombinant BMP7 has surgical uses and is marketed under the brand name OP1. It can be used to aid in the fusion of vertebral bodies to prevent neurologic trauma.[4] Also in the treatment of tibial non-union, frequently in cases where a bone graft has failed.[5] BMP7 also has the potential for treatment of chronic kidney disease.[6][7] BMP7 administration has been proposed as a possible treatment for human infertility.[8] It was discovered that mice injected with BMP7 increased their production of good brown fat cells. [9]

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注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
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3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。