人蛋白酶3(PR3)检测试剂盒,BR

产品属性 Product Attributes

基本信息

中文名称： 人蛋白酶3(PR3)检测试剂盒
英文名称： Human Proteinase 3/Myeloblastin/PRTN3 ELISA Kit
别名： Proteinase 3; ACPA; AGP7; azurophil granule protein 7; C-ANCA; Leukocyte proteinase 3; MBN; MBT; Myeloblastin; Neutrophil proteinase 4; NP4; NP-4; PR-3CANCA; PRTN3; Wegener granulomatosis autoantigen
储存条件： 2-8℃，6 months
规格： 96T ; 48T
检测目标： Proteinase 3/Myeloblastin/PRTN3
样品类型： 血清/血浆/细胞培养上清
反应性： Human
应用： ELISA
定量/定性： 定量检测
检测范围： 31.25-2000pg/mL
灵敏度： 15.625pg/mL
精密度： 板内，板间变异系数均<10%
回收率： 80%-120%

Elisa信息

Swiss Prot： P24158
Gene ID： 5657
背景说明： Proteinase 3 (PRTN3), also known as Myeloblastin (MBN), is a 32-33 kDa member of the peptidase S1 family of enzymes. It is expressed by monocytes and neutrophils, the latter of which either secretes it, sequesters it in azurophilic granules, or expresses it on the cell surface. When secreted, it acts on HK and activates the kinin pathway. In azurophilic granules, it aids in the digestion of phagocytosed material. On the cell surface, it likely acts on ECM. Human PRTN3 proprecursor is 231 amino acids (aa) in length. It contains an Ala26Glu27 propeptide that is removed during maturation, a 221 aa mature enzyme (aa 28-248), and an eight aa C terminal propeptide (aa 249-256). Within the cell, a 35 kDa immature form exists; on the cell surface, both constitutively inactive, and induced active forms may be found, often in a noncovalent association with CD177/NB1. Over aa 26-249, human PRTN3 shares 68% aa identity with mouse PRTN3.

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