大鼠白血病抑制因子受体检测试剂盒,BR

产品属性 Product Attributes

基本信息

中文名称： 大鼠白血病抑制因子受体检测试剂盒
英文名称： Rat CD118/LIFR ELISA Kit
别名： CD118; LIFR; CD118; Leukemia Inhibitory Factor Receptor Alpha; Leukemia Inhibitory Factor Receptor; LIFR Beta; LIF Receptor; LIFR Alpha; LIFR; LIF-R; LIFRa; SJS2; STWS; SWS
储存条件： 2-8℃，6 months
规格： 48T ; 96T
检测目标： CD118/LIFR
样品类型： 血清/血浆/细胞培养上清
反应性： Rat
应用： ELISA
定量/定性： 定量检测
检测范围： 46-3000pg/mL
灵敏度： 23pg/mL
精密度： 板内，板间变异系数均<10%
回收率： 80%-120%

Elisa信息

Swiss Prot： O70535
Gene ID： 81860
背景说明： LIFR (leukemia inhibitory factor receptor) belongs to the family of cytokine receptors. LIFR forms a high-affinity receptor complex with gp130, which mediates the activity of LIF (leukemia inhibitory factor) and thus affects the differentiation, proliferation, and survival of a wide variety of cells in the adult and the embryo. Besides LIF, LIFR can also bind to and activate CNTF (ciliary neurotrophic factor) and CLC (cardiotrophin like cytokine). Evidence showed that in the retina, LIFR activating LIF, CT-1 and cardiotrophin like cytokine (CLC) are strongly upregulated in response to preconditioning with bright cyclic light leading to robust activation of signal transducer and activator of transcription-3 (STAT3) in a time-dependent manner. Further, blocking LIFR activation during preconditioning using a LIFR antagonist (LIF05) attenuated the induced STAT3 activation and also resulted in reduced preconditioning-induced protection of the retinal photoreceptors. These data demonstrate that LIFR and its ligands play an essential role in endogenous neuroprotective mechanisms triggered by preconditioning-induced stress. LIFR was newly found to be a suppressor of hepatocellular carcinoma (HCC), one of the world's top five causes of cancer-related deaths.

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3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。