Anti-FEN1 Monoclonal Antibody,BR

产品属性  Product Attributes

基本信息

英文名称：Anti-FEN1 Monoclonal Antibody

中文名称：瓣结构特异性核酸内切酶1抗体

规格：100ul ; 50ul

宿主：Mouse

克隆类型：Monoclonal Antibody

亚型：IgG1

克隆号：7H8-F4-C11

交叉反应：Mouse ; Rat ; Monkey ; Hamster ; Human

应用：IF ; ICC ; WB

稀释比例：WB 1:500-1000. IF 1:50-200. ICC 1:50-200.

抗体信息

靶标：FEN1

别名：FEN-1;MF1;RAD2;DNase IV;Flap endonuclease 1;flap structure endonuclease 1;hFEN 1;Maturation factor 1

背景说明：The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate,thus passing the substrate from one enzyme to another.The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication.DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene.Therefore,secondary structure can deter the protective function of this protein,leading to site-specific trinucleotide expansions.[provided by RefSeq,Jul 2008]

Swiss Prot：P39748

Gene ID：2237

亚细胞定位：Mitochondrion Nucleus nucleolus nucleoplasm

免疫原：Recombinant protein of human FEN1

理论分子量：36/43kDa

其它标识

纯化方法：Affinity purification

储存液：PBS with 0.02% sodium azide，0.5% BSA，50% glycerol，pH7.3.

储存条件：Store at -20℃. Avoid freeze / thaw cycles.

产品介绍  Product Introduction

使用前请离心。如有问题请及时联系我们。

Quick spin before use. If you have any questions, please contact us.

注意事项  Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。

2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。

3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。