Anti-CDK5 Monoclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-CDK5 Monoclonal Antibody
中文名称： 细胞周期依赖性蛋白激酶5抗体
规格： 100ul ; 50ul
宿主： Mouse
克隆类型： Monoclonal Antibody
亚型： IgG1克隆号 2E8-F9-B7-C11
交叉反应：： Mouse ; Rat ; Monkey ; Human
应用： IF ; ICC ; WB
稀释比例： WB 1:500-1000. IF 1:50-200. ICC 1:50-200.

抗体信息

靶标： CDK5
别名： Cdk 5, Cell division protein kinase 5, Crk6, Cyclin dependent kinase 5, Protein kinase CDK5 splicing, PSSALRE, Serine threonine protein kinase PSSALRE, Tau protein kinase II catalytic subunit, TPKII catalytic subunit, CDK5_HUMAN
背景说明： Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through the cell cycle in concert with their regulatory subunits, the cyclins. Although there are 12 different cdk genes, only 5 have been shown to directly drive the cell cycle (Cdk1, -2, -3, -4, and -6). Following extracellular mitogenic stimuli, cyclin D gene expression is upregulated. Cdk4 forms a complex with cyclin D and phosphorylates Rb protein, leading to liberation of the transcription factor E2F. E2F induces transcription of genes including cyclins A and E, DNA polymerase and thymidine kinase. Cdk4-cyclin E complexes form and initiate G1/S transition. Subsequently, Cdk1-cyclin B complexes form and induce G2/M phase transition. Cdk1-cyclin B activation induces the breakdown of the nuclear envelope and the initiation of mitosis. Cdks are constitutively expressed and are regulated by several kinases and phosphastases, including Wee1, CDK-activating kinase and Cdc25 phosphatase.
Swiss Prot： Q00535
Gene ID： 1020
亚细胞定位： Cell junction Cell membrane Cell projection Cytoplasm Nucleus Perikaryon Peripheral membrane protein growth cone lamellipodium postsynaptic cell membrane postsynaptic density synapse
免疫原： Recombinant protein of human CDK5(N-term)
理论分子量： 33kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 0.02% sodium azide，0.5% BSA，50% glycerol，pH7.3.
储存条件： Store at -20℃. Avoid freeze / thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.

注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。