Anti-TAB1(N-term) Monoclonal Antibody,BR

英文名称:Anti-TAB1(N-term) Monoclonal Antibody
宿主:Mouse
别名:TAB 1;TAK1;TGF beta activated kinase 1 binding protein 1;MAP3K7IP 1

交叉反应:Human
应用:WB
稀释比例:WB 1:1000.
蛋白分子量:55kDa
Gene ID:10454
保存:Store at -20°C. Avoid freeze / thaw cycles.
储存液:Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法:Affinity purification
亚型:unknown
免疫原:Purified recombinant human TAB1(N-terminus) protein fragments expressed in E.coli.
性状:液体
亚细胞定位:Cytoplasm Nucleus
Swiss Prot:Q15750
克隆号:3D10-G10-B6
背景资料:

The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported
Public Immunogen Range:Purified recombinant human TAB1(N-terminus) protein fragments expressed in E.coli.
克隆类型:Monoclonal Antibody
规格:50ul, 100ul,

注意：
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