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Anti-DDB1 Monoclonal Antibody,BR
Anti-DDB1 Monoclonal Antibody
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产品属性 Product Attributes
基本信息
英文名称: Anti-DDB1 Monoclonal Antibody中文名称: DNA损伤结合蛋白1抗体
规格: 100ul ; 50ul
宿主: Mouse
克隆类型: Monoclonal Antibody
亚型: IgG2b克隆号 2D6-B5-E6
交叉反应:: Mouse ; Rat ; Monkey ; Human
应用: WB
稀释比例: WB 1:500-1000.
抗体信息
靶标: DDB1别名: DDBA;UV-DDB1;XAP1;XPCE;XPE;XPE-BF
背景说明: The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit.This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage.Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas.However,it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit.In addition,Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients.The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins.[provided by RefSeq,May 2012]
Swiss Prot: Q16531
Gene ID: 1642
亚细胞定位: Cytoplasm Nucleus
免疫原: Recombinant protein of human DDB1
理论分子量: 127kDa
其它标识
纯化方法: Affinity purification储存液: PBS with 0.02% sodium azide,0.5% BSA,50% glycerol,pH7.3.
储存条件: Store at -20℃. Avoid freeze / thaw cycles.
产品介绍 Product Introduction
使用前请离心。如有问题请及时联系我们。Quick spin before use. If you have any questions, please contact us.
注意事项 Considerations
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。2.为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响,相关处理只限于产品本身,不涉及其他赔偿。