Anti-CBL Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-CBL Polyclonal Antibody
中文名称： 原癌蛋白CBL2抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Mouse ; Rat ; Human
应用： IHC ; WB ; IF ; IP
稀释比例： WB 1:1000-5000. IHC 1:50-100. IF 1:100-500. IP 0.5μg-4μg.

抗体信息

靶标： CBL
别名： C-CBL;CBL2;FRA11B;NSLL;RNF55
背景说明： This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder.
Swiss Prot： P22681
Gene ID： 867
亚细胞定位： Cell membrane Cytoplasm
免疫原： Recombinant protein of human CBL
Public Immunogen Range： 850-906aa
理论分子量： 100kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 0.02% sodium azide，50% glycerol，pH7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

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注意事项 Considerations

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