Anti-SH2D1A Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-SH2D1A Polyclonal Antibody
中文名称： SH2结构域蛋白1A抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Mouse ; Human
应用： IF ; WB
稀释比例： WB 1:500-2000. IHC 1:50-200.

抗体信息

靶标： SH2D1A
别名： DSHP;EBVS;IMD5;LYP;MTCP1;SAP;SAP/SH2D1A;XLP;XLPD;XLPD1
背景说明： This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.
Swiss Prot： O60880
Gene ID： 4068
亚细胞定位： Cytoplasm
免疫原： Recombinant protein of human SH2D1A
Public Immunogen Range： 1-128aa
理论分子量： 14kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 0.02% sodium azide，50% glycerol，pH7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

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注意事项 Considerations

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