Anti-KIR2DS4 Polyclonal Antibody,BR

英文名称:Anti-KIR2DS4 Polyclonal Antibody
宿主:Rabbit
别名:CD158I;KIR-2DS4;KIR1D;KIR412;KKA3;NKAT-8;NKAT8
交叉反应:Human
应用:WB IF
稀释比例:WB 1:500-2000. IF 1:50-200.
蛋白分子量:34kDa
Gene ID:3809
保存:Store at -20°C. Avoid freeze / thaw cycles.
储存液:Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法:Affinity purification
亚型:IgG
免疫原:Recombinant protein of human KIR2DS4
性状:液体
亚细胞定位:Cell membrane Single-pass type I membrane protein
Swiss Prot:P43632
背景资料:

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
Public Immunogen Range:Recombinant protein of human KIR2DS4
克隆类型:Polyclonal Antibody
规格:50ul, 100ul,

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