Anti-RAD17 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-RAD17 Polyclonal Antibody
中文名称： 细胞周期检查点蛋白RAD17抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Human
应用： IP ; WB
稀释比例： WB 1:500-2000. IP 0.5μg-4μg.

抗体信息

靶标： RAD17
别名： RAD17,CCYC,HRAD17,R24L,RAD17SP,RAD24
背景说明： The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified.
Swiss Prot： O75943
Gene ID： 5884
亚细胞定位： Nucleus
免疫原： Recombinant protein of human RAD17
Public Immunogen Range： 391-670aa
理论分子量： 77kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 0.02% sodium azide，50% glycerol，pH7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

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