Anti-PDP1 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-PDP1 Polyclonal Antibody
中文名称： 蛋白磷酸酶 2C, 镁依赖性催化亚基抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Rat ; Human ; Mouse
应用： IHC ; WB
稀释比例： WB 1:500-2000. IHC 1:50-200.

抗体信息

靶标： PDP1
别名： PDH, PDP 1, PDP, PDP1, PDPC 1, PDPC, Protein phosphatase 2C, protein phosphatase 2C, magnesium dependent, catalytic subunit, Pyruvate dehydrogenase phosphatase, catalytic subunit 1, PDP1_HUMAN
背景说明： Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported; one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Swiss Prot： Q9P0J1
Gene ID： 54704
亚细胞定位： Mitochondrion matrix
免疫原： Recombinant protein of human PDP1
Public Immunogen Range： 278-537aa
理论分子量： 61kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 0.02% sodium azide，50% glycerol，pH7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

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注意事项 Considerations

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