Anti-SIGLEC12 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-SIGLEC12 Polyclonal Antibody
中文名称： 唾液酸结合性免疫球蛋白样凝集素12抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Mouse
应用： WB
稀释比例： WB 1:500-2000.

抗体信息

靶标： SIGLEC12
别名： FLJ38600, S2V, sialic acid binding Ig-like lectin 12 (gene/pseudogene), Sialic acid-binding Ig-like lectin 12, Sialic acid-binding Ig-like lectin-like 1, Sialic acid-binding immunoglobulin-like lectins, SIG12_HUMAN, Siglec-12, Siglec-L1, SIGLEC-like 1, SIGLEC-like gene, SIGLEC-like protein 1, Siglec-XII, Siglec12, SLG
背景说明： Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternative splicing results in multiple transcript variants.
Swiss Prot： Q96PQ1
Gene ID： 89858
亚细胞定位： Membrane Single-pass type I membrane protein
免疫原： Recombinant protein of human SIGLEC12
Public Immunogen Range： 20-210aa
理论分子量： 65kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 0.02% sodium azide，50% glycerol，pH7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.

注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。